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Betahistine Mesylate

Name:

Betahistine Mesylate

Synonyms N-Methyl-2-pyridineethylamine dimethanesulphonate
Molecular Structure:  
Molecular Formula C8H12N2.2(CH4O3S)
Molecular Weight: 328.4
Cas. No.: 54856-23-4
EINECS: 259-377-7
Standard: BP, USP
Description:

Betahistine hydrochloride (brand names Serc, Hiserk, Betaserc) is an antivertigo drug. It was first registered in Europe in 1970 for the treatment of Ménière's disease. It is commonly prescribed to patients with balance disorders or to alleviate vertigo symptoms associated with Ménière's disease.
Betahistine comes in tablet form and is taken orally. It is rapidly and completely absorbed. The mean plasma half-life is 3–4 hours, and excretion is virtually complete in the urine within 24 hours. Plasma protein binding is very low. Betahistine is transformed into aminoethylpyridine and hydroxyethylpyridine and excreted with the urine as pyridylacetic acid. There is some evidence that one of these metabolites, aminoethylpyridine, may be active and exert effects similar to those of betahistine on ampullar receptors

 

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